Endocrine Abstracts

Introduction: 39% of morbidly obese patients have type 2 diabetes mellitus (T2DM) and 80% of them can achieve diabetes remission after bariatric surgery. However, there are few randomized studies comparing the metabolic results of different surgical techniques and the hormonal mechanisms involved.Objective: To study and compare the improvement of T2DM and the hormonal pathways following three surgical techniques: metabolic gastric bypass (mGBP), sleeve g...

Introduction: In vitro and animal studies have suggested that changes in the secretion of ghrelin, PYY, GLP-1, GLP-2 can influence bone metabolism. An increase in osteoblastic differentiation has been observed after the administration of ghrelin and GLP-1. GLP-2 has been associated with a decrease in bone resorption and PYY inversely with markers of bone formation.Objective: To analyze the association of gastrointestinal hormones with changes in...

Background: Mid-life obesity is a risk factor for Alzheimer’s disease (AD). On the contrary, late-life obesity has been identified as a protective factor for dementia. Recent published studies have shown that weight loss predicts and precedes dementia diagnosis by decades. Thus, paradoxical effect of body weight across lifespan, the so called “obesity paradox”, might be explained by reverse causality. Structural magnetic resonance imaging (MRI) has been extensiv...